New Glossary Entry: The AstraZeneca Effect

The AstraZeneca Effect describes the impact of the AstraZeneca CoViD Vaccine trials. The earliest “variants of concern” occurred in and only in the places where AstraZeneca did their trials:

AstraZeneca did their initial trials in the UK, Brazil, South Africa & India

The World Health Organizations initial variants of concern, alpha, beta, gamma & delta were first detected in the UK, Brazil, South Africa & India.

Just in case the articles disappear, here are the full texts:

 
astrazeneca.com

 

COVID-19 vaccine AZD1222 clinical trial resumed in Japan, follows restart of trials in the UK, Brazil, South Africa and India

 

The Phase I/II clinical trial for the COVID-19 vaccine AZD1222 has resumed in Japan after discussion with the Japanese Pharmaceuticals and Medical Devices Agency (PMDA).

A standard review process triggered a voluntary pause to vaccination across all global trials on 6 September to allow review of safety data by an independent committee. Their recommendations have been supported by international regulators in the UK, Brazil, South Africa, India and now in Japan, who have deemed that the trials are safe to resume.

AstraZeneca continues to work with the Food and Drug Administration (FDA) to facilitate review of the information needed to make a decision regarding resumption of the US trial. The safety of trial participants is of paramount importance and we are committed to upholding the highest standards of conduct in clinical trials.

AZD1222

AZD1222 was co-invented by the University of Oxford and its spin-out company, Vaccitech. It uses a replication-deficient chimpanzee viral vector based on a weakened version of a common cold virus (adenovirus) that causes infections in chimpanzees and contains the genetic material of the SARS-CoV-2 virus spike protein. After vaccination, the surface spike protein is produced, priming the immune system to attack the SARS-CoV-2 virus if it later infects the body.

AstraZeneca

AstraZeneca (LSE/STO/Nasdaq: AZN) is a global, science-led biopharmaceutical company that focuses on the discovery, development and commercialisation of prescription medicines, primarily for the treatment of diseases in three therapy areas – Oncology, Cardiovascular, Renal & Metabolism, and Respiratory & Immunology. Based in Cambridge, UK, AstraZeneca operates in over 100 countries and its innovative medicines are used by millions of patients worldwide. Please visit astrazeneca.com and follow the Company on Twitter @AstraZeneca.

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bbc.com

 

What are the Delta, Gamma, Beta and Alpha Covid variants?

By Michelle Roberts

By Michelle Roberts
Health editor, BBC News online

coronavirusimage source, Getty Images

An outbreak of cases of the Delta variant of Covid is causing concern in China.

More than 300 cases have been spotted in 10 days – leading to increased testing and travel restrictions.

What is the Delta variant?

There are thousands of different types – or variants – of Covid circulating across the world. One of them, known as Delta or B.1.617.2, appears to be spreading quickly in many countries including the UK, where it has become the dominant variant.

The UK classes Delta as a “variant of concern” – these are kept under the closest watch by health officials.

Other current variants of concern also include:

  • Alpha (B.1.1.7), first identified in the UK but which spread to more than 50 countries
  • Beta (B.1.351), first identified in South Africa but which has been detected in at least 20 other countries, including the UK
  • Gamma (P.1), first identified in Brazil but which has spread to more than 10 other countries, including the UK

Viruses mutate all the time and most changes are inconsequential. Some even harm the virus. But others can make the disease more infectious or threatening – and these mutations tend to dominate.

Graphic shows current names for covid variants and WHO's proposed Greek names

Is Delta more dangerous?

There is no evidence that Delta – or any of the other variants – cause more serious illness for the vast majority of people.

As with the original version, the risk remains highest for people who are elderly or have significant underlying health conditions.

But even so, if a variant is more infectious it will lead to more deaths in an unvaccinated population.

Vaccines offer high protection against severe illness with Covid-19, including infections caused by variants of concern. The shots also reduce the risk of infection. But they are not perfect and do not completely eliminate all risk.

It is unclear how many people in China are fully vaccinated, although authorities say more than 1.6 billion doses have been administered so far.

The advice to avoid infection remains the same for all strains: wash your hands, keep your distance, wear a face covering and be vigilant about ventilation.

How are the mutants behaving?

The variants of concern have all undergone changes to their spike protein – the part of the virus which attaches to human cells.

Delta has some potentially important ones (such as L452R) that might make it spread more easily.

There is no evidence to indicate it causes more severe disease or might make current vaccines less effective, say UK officials.

One mutation, called N501Y, shared by the Alpha, Gamma and Beta, seems to make the virus better at infecting cells and spreading.

Experts have found a small number of cases of Alpha with this change too.

Chart showing what the variants are and how they happen

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Will vaccines still work against variants?

Current vaccines were designed for earlier versions of coronavirus, which means they may not be the ideal match for new variants and so might not work quite as well.

But experts say they are still very effective at protecting lives by cutting the risk of severe illness:

  • An analysis by Public Health England found two doses of either the Pfizer or AstraZeneca vaccine was more than 90% effective against hospitalisations for Covid-19 caused by Delta
  • A single dose, however, was less effective at preventing illness from Delta, compared to how well it worked against Alpha.

Doctors say it is vital that people get both doses to gain maximum protection against existing and emerging variants.

Do variants mean booster jabs are more likely?

Experts are confident existing vaccines can be redesigned to better tackle emerging mutations.

The UK government has a deal with biopharmaceutical company CureVac to develop vaccines against future variants, and has pre-ordered 50 million doses.

Depending on how variants continue to develop, these could potentially be used to offer a booster vaccine to older or clinically vulnerable people later in the year.

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